Supplements

Creatine Explained: The Science Behind the Strength Supplement

Written by Kat Kennedy, NASM CPT, NCSF CPT, NCSF SNS
Medically Reviewed by Dr. Elaine Gavalas, ND, PhD

April 14, 2025

Are you looking for a safe, effective way to maintain muscle strength and energy as you age? In the vast sea of supplements making bold claims, creatine monohydrate stands out as one with exceptional scientific backing.

While often misunderstood as just a supplement for young male athletes, this remarkable compound offers significant benefits for people of all ages and genders—with particular advantages for those in their 40s, 50s, 60s, and beyond.

If you've been curious about how to maintain your strength and energy through the years, this comprehensive guide will walk you through everything you need to know about creatine monohydrate—from what it is to how it works in your body and how you can incorporate it into your wellness routine.

Table Of Contents

What Is Creatine Monohydrate?

Creatine is a naturally occurring compound that plays a vital role in energy production within your body. It's not some artificial chemical but rather a substance your body already makes and uses every day. Your liver, kidneys, and pancreas produce about 1 gram of creatine daily, and you get additional amounts (roughly 1-2 grams) from animal proteins like meat and fish (1).

Creatine monohydrate is simply the supplemental form of this compound—creatine with one molecule of water attached. It's designed to increase your body's creatine stores beyond what diet alone provides, allowing for enhanced energy production during physical activity.

Inside your body, creatine is primarily stored in your muscles (about 95%), with small amounts in your brain and other tissues. There, it plays a crucial role in the production of adenosine triphosphate (ATP), which is essentially your body's energy currency.

Think of creatine as your body's energy reserve system, helping to rapidly regenerate ATP during short, intense bursts of activity.

How Creatine Works: The Science Made Simple

To understand why creatine is so effective, it helps to know a little about how your muscles produce energy. When you engage in any physical activity—whether it's lifting weights, walking your dog, or carrying groceries—your muscles use ATP for energy.

Think of it this way: Your muscles have a small battery that provides instant power for intense activities like lifting weights or sprinting. This battery uses a substance called ATP for energy.

The problem is, this battery runs out of power very quickly—in just 5-10 seconds of hard effort. That's where creatine comes in. Your body stores creatine in your muscles as phosphocreatine. When you need energy quickly, phosphocreatine donates its phosphate group to ADP (adenosine diphosphate), converting it back to ATP, providing an immediate energy source (2).

By supplementing with creatine monohydrate, you can increase your muscles' phosphocreatine stores, providing more immediate energy during high-intensity activities and allowing your muscles to perform better before fatigue sets in.

The Most Researched Supplement in History

What many people don't realize is that creatine monohydrate is the most thoroughly researched supplement on the market today. With over 1,000 peer-reviewed studies spanning more than three decades, its safety and effectiveness profile is exceptionally well-documented (3).

The International Society of Sports Nutrition's position on creatine states: "Creatine monohydrate is the most effective ergogenic nutritional supplement currently available to athletes in terms of increasing high-intensity exercise capacity and lean body mass during training” (4).

Creatine has more scientific backing than almost any nutritional supplement in history. This extensive research provides peace of mind, especially for those who approach supplements with careful consideration.

The Health Benefits of Creatine

The remarkable benefits of creatine extend far beyond just helping young athletes build muscle. Here's what the science shows:

1. Improves Muscle Function

Creatine’s direct role in ATP production means it can help improve high-intensity exercise performance (3, 5, 6).Take the battery analogy from earlier, when you take creatine, it's like upgrading your phone's battery capacity—suddenly you can do more work before running out of power. 

One review found that it improves high-intensity exercise performance by up to 15% (7).

A screenshot of an NCBI study titled "Effects of creatine supplementation on performance and training adaptations"

Another study reported that participants’ cycling performance increased by 10% when they took a monohydrate powder, but did not increase when they took liquid creatine (8).

While we often focus on creatine's benefits for high-intensity exercise, the improved energy production helps with all activities. Many older adults report feeling more energetic throughout their day when supplementing with creatine. This means more stamina for gardening, playing with children or grandchildren, or maintaining an active lifestyle at any age.

2. Increases Muscle Mass (& Preserves It with Age)

Creatine doesn’t just provide your muscles with energy, it also works as a muscle builder and protective agent to support strength and physical function throughout life. Creatine boosts the activity of special repair cells (called satellite cells) that maintain and rebuild muscle tissue. It also increases water content inside muscle cells, creating a protective shield against muscle wasting, since well-hydrated cells are less likely to break down their proteins.

A 2022 review found that healthy young adults who take creatine supplements gain more muscle than those who don't (9).

It's not just helpful for young people either. After age 30, most people begin losing muscle mass at a rate of 3-8% per decade, with this loss accelerating after age 60 (10). This natural process—called sarcopenia—can lead to weakness, frailty, increased risk of falling, and loss of independence.

Creatine helps preserve muscle mass by acting as a cellular protector during periods when you might otherwise lose muscle. It keeps your muscle cells properly hydrated and full, which naturally reduces muscle breakdown. 

A review published in 2019 discovered that older adults who take creatine build more muscle and get stronger, even if they don't exercise much (11). This extra strength helps prevent falls, which is especially important as people age.

3. Supports Bone Health

Creatine doesn't just build muscle—it helps keep your bones strong too. Creatine may help support bone health by enhancing the function of bone-building cells called osteoblasts, while potentially reducing the activity of bone-resorbing osteoclasts (12). 

Creatine also helps bones indirectly. When your muscles get stronger from creatine, they pull harder on your bones during movement. This extra pulling actually signals your bones to become denser and stronger—similar to how lifting weights makes both your muscles and bones adapt and strengthen together.

Research suggests that creatine supplementation, especially when combined with resistance training, might increase bone mineral density and improve markers of bone turnover, which could be particularly beneficial for older adults at risk of osteoporosis (13).

4. Supports Brain Function

It’s no surprise your brain needs a lot of energy, especially when tackling complex mental tasks (14). Creatine plays a key role in powering these brain activities in several ways:

First, creatine helps your brain produce energy more efficiently. When you take creatine supplements, they increase phosphocreatine stores in your brain, which helps generate more ATP—your brain's primary energy currency.

Beyond energy production, creatine appears to support brain function by boosting dopamine levels (an important neurotransmitter) and improving how your brain cells' power plants (mitochondria) work  (14, 15, 16).

Vegetarians often see significant benefits from creatine supplementation because meat is the main dietary source of creatine. Studies show vegetarians taking creatine supplements experienced a 20-50% improvement on memory and intelligence tests (14).

A screenshot of an NCBI study titled "Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial."

Older adults also benefit substantially—just two weeks of creatine supplementation significantly improved their memory and recall abilities (17).

While these findings are promising, more research is still needed to determine how much creatine benefits younger, healthy people who have a diet sufficient in lean meat and fish.

5. May Help Manage Blood Sugar Levels

Research suggests that creatine supplements might help keep your blood sugar levels healthy by boosting the activity of a molecule called glucose transporter type 4 (GLUT-4). 

Think of GLUT-4 as tiny doors on your muscle cells that open to let sugar from your bloodstream enter your muscles. When these doors work better, more sugar moves from your blood into your muscles, which can help maintain steadier blood sugar levels throughout your body (18, 19, 20, 21).

A 12-week study examined how creatine affects blood sugar levels after a high carb meal. People who combined creatine and exercise exhibited better blood sugar control than those who only exercised (20).

Short-term blood sugar response to a meal is an important marker of diabetes risk. The faster your body clears sugar from the blood, the better (22).

Native Note: While these benefits are promising, more human research is needed on creatine’s long-term effects on blood sugar control and diabetes.

Proper Dosage Guidelines: Keeping It Simple

Dosing creatine is straightforward, though recommendations may vary based on body size (23):

Loading Phase:

  • For women: 3-5 grams, 4 times daily for 5-7 days
  • For men: 5 grams, 4 times daily for 5-7 days

Maintenance Phase:

  • For women: 3-5 grams daily
  • For men: 5 grams daily

Many people find they can achieve excellent results without the loading phase by simply taking the maintenance dose consistently. The loading phase simply saturates your muscles with creatine more quickly, allowing you to experience benefits sooner. 

However, a loading phase isn't necessary, especially for those who may be concerned about digestive discomfort. Starting with a dose of 3-5 grams daily will still effectively saturate your muscles within 3-4 weeks.

How to Incorporate Creatine Into Your Routine

Consistency is key with creatine. Here's a simple approach to make it part of your daily routine:

  • Choose a consistent time: Take your daily dose at the same time each day to establish a routine. Many people find taking it with breakfast or after a workout works well. Personally I take mine first thing in the morning, right before my workout. 
  • Keep it simple: Creatine monohydrate is tasteless or has a very mild taste. It can be easily mixed into water, smoothies, or any beverage of your choice.

Native Note: Avoid mixing your creatine in coffee, emerging research shows that caffeine may interfere with its efficacy.

  • Be patient: While some people notice benefits within the first week, the full effects typically become noticeable after 4-6 weeks of consistent use.
  • Stay hydrated: Since creatine draws water into your muscle cells, ensuring adequate hydration maximizes its benefits.

As always, consult with your physician or healthcare provider before starting creatine to determine the right dose for you—especially if you have existing health conditions or take medications.

The Bottom Line

Creatine monohydrate offers remarkable benefits for people of all ages and backgrounds, with particular advantages for those looking to maintain strength, energy, and vitality as they age. With its exceptional safety profile and abundant scientific backing, it represents one of the most sensible supplements available.

As with any supplement, it's wise to consult with your healthcare provider before starting, especially if you have pre-existing medical conditions. But for most people, creatine offers a safe, effective addition to an active lifestyle and balanced diet.

Remember, maintaining muscle strength isn't just about aesthetics—it's about preserving independence, mobility, and quality of life for years to come. In a world full of supplement hype and empty promises, creatine monohydrate stands out as one supplement that actually delivers on its promises.

Whether you're 25 or 75, male or female, athlete or gardener, creatine monohydrate might just be the supplement your wellness routine has been missing.

Kat Kennedy
Article by

Kat Kennedy

Kat Kennedy is the Fitness and Nutrition Editor at NativePath. With a NASM CPT, NCSF CPT, and NCSF Sports Nutrition Certification, she has a passion for giving people the tools they need to feel healthy, strong, and confident.

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Medical Disclaimer

This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Chad Walding nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement, or lifestyle program.

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